Coumarins and derivatives
TARGETMOL CHEMICALS INC 7-ACETOXY-4-METHYLCOUMAR 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media a cell membrane environmental mimic to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum. purity: 88%
Cayman Chemical 7-Acetoxy-4-methylcoumarIn 5g
A fluorogenic substrate for carboxylesterase and AChE; upon hydrolysis by carboxylic esterase or AChE, 4-MU is released, which displays pH-dependent excitation maxima of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm; has been used to detect the presence of carboxylesterases in isolated human lung tissue
Accela Chembio Inc MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | >98.0% | 281.35 | C18H19NO2 | 50 MG
Coumarin 106 is a dipolar laser dye used in research that also functions as a cholinesterase inhibitor. It exhibits mixed-type inhibition of acetylcholinesterase (reported pIC50 4.97, Ki 2.36 μM) and lower potency against butyrylcholinesterase (pIC50 4.56). Molecular formula C18H19NO2 and molecular weight 281.35. In vitro data report no toxicity in Caco-2 cells.
- Dipolar laser dye useful for fluorescence and photonic applications.
- Inhibits acetylcholinesterase with reported pIC50 4.97 and Ki 2.36 μM.
- Also inhibits butyrylcholinesterase with pIC50 4.56.
- Molecular weight 281.35 and formula C18H19NO2.
- Reported non-toxic in Caco-2 cell assays.
- Supplied as a 50 mg research reagent.
Medchemexpress LLC Coumarin 314 | 55804-66-5 | MFCD00051334 | 98.0% | 313.3 g/mol | C18H19NO4 | 500 MG
Coumarin 314 is a fluorescent dye that exhibits intense absorption in the visible region and pronounced solvent-dependent spectral behavior. It is used as a visible-absorbing fluorophore for photophysical studies, fluorescence labeling, and materials research, and is supplied with analytical documentation for research use.
- Intense absorption in the visible region.
- Pronounced solvent-dependent spectral behavior.
- High stated purity of 98.0%.
- Available in small research quantities (100 mg, 250 mg, 500 mg; larger sizes by request).
- Manufacturer provides SDS, COA, and a data sheet for each batch.
- Suitable for fluorescence labeling and photophysical studies.
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 25mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Selleck Chemical LLC 7-Methylcoumarin-E0656-100MG
7-Methylcoumarin can inhibit the growth of S aureus and the growth of Gram-positive bacteria within a concentration of 0 8 3 6 g/ml and also has a strong hepatoprotective activity
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 100mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC 2-oxo-2H-1-benzopyran-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 50 G
Coumarin-3-carboxylic acid is a small-molecule research reagent (2-oxochromene-3-carboxylic acid) used as a fluorescent probe for hydroxyl radicals and as a synthetic building block. Supplied as a high-purity solid, it is suitable for in vitro studies and can be formulated for in vivo dosing when required.
Cayman Chemical 7-EthoxycoumarIn 500mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 10mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.9% | 453.94 | 50 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors.
- Inhibits epidermal growth factor receptor.
- Inhibits phosphoinositide 3-kinase.
- Demonstrates anti-tumor effects.
- Acts as a weak agonist of peroxisome proliferator-activated receptors.
- Helps alleviate hyperglycemia.
- Suppresses tumor proliferation.
Medchemexpress LLC Coumarin 6 | 38215-36-0 | 1 ML
Coumarin 6 is a fluorescent dye utilized as a fluorescent probe within microparticle drug delivery systems. It is employed to conduct in vivo tracking, cellular uptake studies, and investigations into the transport mechanisms of drug delivery systems. It has an excitation wavelength (λexc) of 450 nm and an emission wavelength (λem) of 505 nm. This product is intended for research use only and is not sold to patients.
- Used for in vivo tracking, cell uptake, and transport mechanism studies in drug delivery systems
- Optimal wavelengths: Excitation at 450 nm and emission at 505 nm
- Purity: 99.59%
Indofine Chemical 7-Diethylaminocou, 98%, 250 Mg
7-DIETHYLAMINOCOUMARIN 250 MG, Coumarin, C13H15NO2, MW: 217.27, 98%, 20571-42-0, MFCD00232946
Medchemexpress LLC Coumarin 480 | 41267-76-9 | MFCD00041844 | 100.0% | 255.31 g/mol | C16H17NO2 | 25 MG
Coumarin 480 (Coumarin 102) is a high-purity fluorescent laser dye used in fluorescence spectroscopy, laser applications, and optical research. It shows strong emission near 480 nm and is supplied as a research-grade reagent for imaging, sensor development, and photophysical studies. Users should follow the product SDS for safe handling and storage.
- High purity (99.95%).
- Strong fluorescence emission near 480 nm.
- Suitable for fluorescence spectroscopy and laser dye applications.
- Useful for sensor development and imaging studies.
- Provided as a research reagent in small vials.