Coumarins and derivatives
Apexbio Technology LLC Palomid 529 914913-88-5 5mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Apexbio Technology LLC Coumarin 6 38215-36-0 10mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 100mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Indofine Chemical MYRICETIN, Flavonoid & Coumarins, 529-44-2, 0.98, 50 mg
MYRICETIN, Flavonoid & Coumarins, 529-44-2, 0.98, 50 mg
Indofine Chemical Luteolin-7-O-Glucosid, 10 Mg
LUTEOLIN-7-O-GLUCOSIDE with HPLC, Flavonoid & Coumarins, 5373-11-5, 98% by HPLC, 10 mg
Indofine Chemical KAEMPFEROL-7-O-NEOHESPERIDOSIDE, Flavonoid & Coumarins, 17353-03-6, >95% by HPLC, 10 mg
KAEMPFEROL-7-O-NEOHESPERIDOSIDE, Flavonoid & Coumarins, 17353-03-6, >95% by HPLC, 10 mg
Apexbio Technology LLC Coumarin 6 38215-36-0 50mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Cayman Chemical ANTIBODY CoumarIn 6 1g
An acid-sensitive fluorescent probe; upon protonation, it displays a shift in emission maxima from 410 nm to 510 nm upon excitation at 157 nm; has been commonly used in photolithography
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 50mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 5mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 10mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 100mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC Esculetin | 305-01-1 | 99.79% | 178.14 | 1 ML
Esculetin is an active ingredient extracted mainly from the bark of *Fraxinus rhynchophylla*. It primarily functions by inhibiting the PI3K/Akt pathway, which affects platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching. Additionally, Esculetin demonstrates antioxidant, anti-inflammatory, and antitumor properties, making it a subject of various research applications. It is intended for research use only and not for medical or patient use.
- Inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cell (ASMC) proliferation and migration.
- Demonstrates antioxidant activity.
- Exhibits anti-inflammatory effects.
- Possesses antitumor activities.
- Targets PI3K pathway.
- Induces apoptosis in certain cancer cell types.
- Ameliorates skin lesions in psoriatic mice models.
Medchemexpress LLC Coumarin hydrazine | 113707-87-2 | MFCD09999551 | 97.1% | 190.20 g/mol | C10H10N2O2 | 50MG
Coumarin hydrazine is an aromatic hydrazine-containing coumarin fluorophore used as a chemical probe to label protein- and lipid-bound carbonyls in cells. It excites in the 420-450 nm range and emits near 468-490 nm, and is provided as a solid reagent for research applications.